File:Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.pdf
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Summary
| Description |
English: Objective
Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2. Participants The records of individuals admitted between April 7 Design Patients admitted to GMC with COVID-19 were categorized according to disease severity and level of 25(OH)D. An association between pre-infection 25(OH)D levels, divided between four categories (deficient, insufficient, adequate, and high-normal), and COVID-19 severity was ascertained utilizing a multivariable regression analysis. To isolate the possible influence of the sinusoidal pattern of seasonal 25(OH)D changes throughout the year, a cosinor model was used. Results Of 1176 patients admitted, 253 had records of a 25(OH)D level prior to COVID-19 infection. A lower vitamin D status was more common in patients with the severe or critical disease (<20 ng/mL [87.4%]) than in individuals with mild or moderate disease (<20 ng/mL [34.3%] p < 0.001). Patients with vitamin D deficiency (<20 ng/mL) were 14 times more likely to have severe or critical disease than patients with 25(OH)D ≥40 ng/mL (odds ratio [OR], 14; 95% confidence interval [CI], 4 to 51; p < 0.001). Conclusions Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality. |
| Date | |
| Source | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069 |
| Author | Amiel A. Dror ,Nicole Morozov,Amani Daoud,Yoav Namir,Orly Yakir,Yair Shachar,Mark Lifshitz,Ella Segal,Lior Fisher,Matti Mizrachi,Netanel Eisenbach,Doaa Rayan,Maayan Gruber,Amir Bashkin,Edward Kaykov,Masad Barhoum,Michael Edelstein,Eyal Sela |
doi:10.1371/journal.pone.0263069
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 23:09, 4 March 2022 |  | 1,275 × 1,650, 18 pages (1.1 MB) | Koavf | Uploaded a work by Amiel A. Dror ,Nicole Morozov,Amani Daoud,Yoav Namir,Orly Yakir,Yair Shachar,Mark Lifshitz,Ella Segal,Lior Fisher,Matti Mizrachi,Netanel Eisenbach,Doaa Rayan,Maayan Gruber,Amir Bashkin,Edward Kaykov,Masad Barhoum,Michael Edelstein,Eyal Sela from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069 with UploadWizard |
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